Observation on Pericytes of Myocardial Capillary in Hypertensive Rats with Diabetes Mellitus

  • Li Zhang
Keywords: Diabetes Mellitus, Hypertension Research, Pericytes of Capillaries, Cardiomyocytes Research

Abstract

To observe the pericytes of myocardial capillaries in hypertensive rats with diabetes mellitus. The two kidney
one clip hypertensive rat model and hypertension combined with diabetes rat model were used. After successful
modeling, they were divided into th ree groups: control group (n = 10); hypertension group (n = 10);
hypertension diabetes group (n = 10). The control group was given normal saline (NS) by gavage. Cardiac
function, hemodynamics, blood glucose, free fatty acids, blood lipids and other related indicators were observed
and analyzed logically. Finally, the data were statistically analyzed. In general, the cardiac index of hypertension
group was significantly higher than that of control group (P < 0.05), and that of hypertension diabetes group was
significantly higher than that of hypertension group (P < 0.05). Compared with the control group, LVSP and
lvdep in hypertension group were higher than those in control group (P < 0.05); LVSP and LVEDP in
hypertension diabetes group were significantly low er than those in hypertension group (P < 0.05). There was no
significant difference in blood glucose and free fatty acid content between the hypertension group and the
control group; compared with the hypertension group, the blood glucose and free fatty ac id content in the
hypertension diabetes group were significantly higher (P < 0.05). Compared with the control group, the level of
FAF in hypertension group was significantly higher than that in control group, and the level of FAF in
hypertension diabetes g roup was also significantly higher than that in hypertension group (P < 0.05). Compared
with hypertension group, TC and LDL C were significantly increased, HDL C was significantly decreased (P <
0.05), but GT had no significant change in hypertension and d iabetes group. Pericytes of myocardial capillaries
may be the main effector cells of myocardial fibrosis in rats and play a role in the early stage of myocardial
fibrosis. Diabetes aggravates the progress of cardiac hypertrophy and cardiac dysfunction in h ypertensive rats.

Published
2020-06-01