Effect of Traditional Chinese Medicine on Ultrastructure of Pulmonary Fibrosis Rats

  • Yunxia Zheng
Keywords: Chinese Medicine, Pulmonary Fibrosis, Ultrastructural Morphology, Influence Mechanism

Abstract

Pulmonary fibrosis is a heterogeneous disease, which is mostly caused by disordered lung tissue structure and
alveolitis. Pulmonary fibrosis can cause severe damage to lung tissue, is extremely harmful to the body, and is
extremely difficult to cure. At present, most of the treatment methods for pulmonary fibrosis are drugs. In the
past few years, Chinese and Western medicine therapy is a mainstream treatment method. With the development
of traditional Chinese medicine, more and more attention has been paid to traditional Chinese medicine therapy.
The purpose of this article is to explore the specific effect and mechanism of Chinese medicine therapy on the
lung tissue ultrastructure of pulmonary fibrosis rats. Taking 60 adult male rats as the experimental object, it is
divided into two groups, 30 in each group, one group was no drug intervention in the control group, and the
other group was the intervention group of Chinese medicine (emodin and astragalus compound formula)
intervention. First, all rats were injected with bleomycin to create a rat model of pulmonary fibrosis. Five days
after the successful modeling, the rats in the observation group were given intragastric treatment. The
transmission electron microscope was used to observe the ultrastructural changes and lung fibrosis in the lung
tissues of the two groups of rats. The results show that under the intervention of Chinese medicine treatment, the
degree of fibrosis in the lung tissue of rats decreased by 22.3%, the number of collagen fibers decreased by
35.8% compared with the control group, and the number of epithelial cells in lung tissue of rats decreased by
27.6%. At the same time, the mitochondria become larger, and the rate of fiber cell value increase. Therefore, it
can be seen that traditional Chinese medicine has a good therapeutic effect on lung tissue fibrosis, and has a
certain protective effect on lung tissue ultrastructure.

Published
2020-06-01