Ultrastructural Characteristics of Nasopharyngeal Carcinoma and the Phenomenon of Lymphocytolysis

  • Miao Zhao
Keywords: Nasopharyngeal Carcinoma, Ultra Microstructure, Lymphocytolysis, Electron Microscopic Observation


In order to further understand the nasopharyngeal carcinoma and improve the treatment level of nasopharyngeal
carcinoma, the ultrastructural characteristics and lymphocytolysis of nasopharyngeal carcinoma were observed.
In this study, 8 patients with nasopharyngeal carcinoma were randomly selected for the study. After ultrathin
section, one case of normal nasopharyngeal epithelium, one case of mucosa adjacent to nasopharyngeal
carcinoma and one case of nasopharyngeal carcinoma epithelium were selected. At the same time, eight
parameters of cell nuclear perimeter (Cn), area (An), volume (Vn), volume density (Vv), number density (Nv),
surface area density (Sv), cell perimeter (Cc) and area (Ac) were calculated by stereological method. The
volume density of nasopharyngeal epithelium was 0.1 and the surface area density was 0.18. The volume
density and surface area density of the epithelial cell nucleus were 0.4 and 0.22 respectively. The volume density
and surface area density of nasopharyngeal carcinoma were 0.445 and 0.265 respectively. It was found that the
tumor killing rate increased with the prolongation of treatment time, and the tumor killing rate was significantly
increased after 24 h than 6 h. The most obvious phenomenon of lympholysis was nasopharyngeal poorly
differentiated squamous cell carcinoma cell line (5-8F).