Confocal Microscopy Study of Corneal Cells in Patients with Diabetic Retinopathy

  • Tingting Li
Keywords: Confocal Microscopy, Diabetic Retinopathy, Corneal Cells, Density and Morphology


With the increase of the prevalence rate, it has recently received more and more attention and attention from the
society. Based on this, this article takes diabetic retinopathy patients as the research object, and uses confocal
microscopy to explore and observe the changes of corneal cells in Diabetic Retinopathy(DR) patients, with a
view to early detection of DR and provide guidance for the clinical diagnosis and treatment of DR patients. In
this study, 50 DR patients and 10 non-diabetic cataract patients were selected as experimental subjects.
According to the DR staging criteria, 50 DR patients were divided into 10 cases of stage I, 10 cases of stage II,
10 cases of stage III, and IV There were 10 cases in stage 10 and 10 cases in stage V. Ten cataract patients
without diabetes were used as a control group. The corneal cells of all patients participating in the study were
observed by confocal microscopy. The results showed that the corneal cells of DR patients were significantly
more than the control group The difference was statistically significant (P<0.05). The density of epidermal cells,
stromal cells, and basal cells in the DR group was significantly reduced compared with the control group. The
central corneal thickness, average cell area, and nerve fiber length and The density was lower than that of the
control group, and the density of nerve branches was higher than that of the control group; the cornea cells in the
DR group were unevenly distributed, the cell edge glowed weakly. This experiment clearly observed the
changes of corneal cells in DR patients through confocal microscopy, which shows that confocal microscopy
has great guiding significance and value for the clinical diagnosis and treatment of DR.