Improved Extracellular Protease Production by Bacillus Subtilis

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Keywords: Bacillus Subtilis, Secretory Proteins, Secreted Enzyme, Gene Regulation


Bacillus subtilis and related bacilli have the capacity to secrete a variety of proteins into their environment, at
frequently high concentrations. This has led to the commercial exploitation of bacilli as cell factories for
secreted enzymes. Regulation of the synthesis of secretory proteins, especially one of the major extracellular
proteases, AprE, has been studied in detail for several years.