Effect of Ursodeoxycholic Acid on Liver Function and Anti-Fibrosis in Cholestasis Rats

  • Jia Yu
Keywords: Ursodeoxycholic Acid, Cholestasis, Young Rats, Liver Function, Anti-Fibrosis

Abstract

To investigate the effect of ursodeoxycholic acid (UDCA) on liver function and anti-fibrosis in cholestasis rats,
and to analyze its target and mechanism. 60 rats with cholestasis were randomly divided into two groups, 30 in
each group. The control group was injected with normal saline, and the observation group was injected with
ursodeoxycholic acid 100mg / kg. 12 weeks later, the liver function and fibrosis of the two groups were
compared. Serum ALT, AST, TBIL, DBIL and ibil were detected by biochemical method, serum HA and PCIII
were detected by radioimmunoassay, and the expression levels of CIV and LN were detected by ELISA.
Compared with the control group, the levels of ALT and AST in the serum of the observation group were
significantly reduced (P < 0.05). Compared with the control group, the expression levels of TBIL, DBIL and ibil
in the serum of the observation group were significantly reduced (P < 0.05). Compared with the control group,
the expression level of HA and PCIII in the serum of the observation group was significantly reduced (P < 0.05).
Compared with the control group, the expression levels of CIV and LN in the observation group were
significantly reduced (P < 0.05). Ursodeoxycholic acid has a very good therapeutic effect on cholestasis. It can
inhibit liver fibrosis, improve liver function, and provide new experimental data and evidence for the prevention
and treatment of cholestasis.

Published
2020-05-01