Aortic Arch Stenosis Caused by Minimally Invasive Surgery in Mouse Heart Failure Model

  • Xin Zhou
Keywords: Aortic Arch Stenosis, Minimally Invasive Surgery, Heart Failure, Application Effect

Abstract

Heart failure refers to damage to the structure and function of the heart caused by various reasons, impairing the
contraction and diastolic function of the ventricle, and causing abnormal hemodynamics. The purpose of this
article is to study the application effect of aortic arch stenosis caused by minimally invasive surgery in the
model of heart failure in mice, establish a model of heart failure in mice by minimally invasive surgery, and
randomly divide the mice into sham operation group and constriction group. The narrowing group underwent
minimally invasive surgery for ligation of the aortic arch through the neck incision, and the sham operation
group was the same as the narrowing group except not ligating. The results of the study showed that the
mortality of aortic arch narrowing during operation and within 24 hours after surgery was 11% (8/75), and the
mortality rate at 1 week after surgery was 7.5% (5/66); the mortality rate during and after surgery was 20%
( 15/75), no one died in the 60 sham operation group. Compared with the sham-operated group, the LVFS%
values of mice with moderate and severe aortic constriction decreased to varying degrees, especially in severely
constricted mice, the decrease was most obvious (43.8+1.08 vs. 21.6+1.18, p <0.01). Therefore, aortic arch
stenosis caused by minimally invasive surgery can successfully prepare a mouse model of heart failure.

Published
2020-05-01