Probiotics Combined with Ursodeoxycholic Acid on Cholestatic Liver Disease during Pregnancy

  • Zhengchuan Li
Keywords: Probiotic Therapy, Ursodeoxycholic Acid, Cholestatic Liver Disease, Clinical Effect, Animal Experiment


Intrahepatic bile duct dysplasia is one of the common causes of non-biliary atresia cholestasis. There are few
medical and surgical treatment measures. If intrahepatic cholestasis is not solved in time, children may progress
to cholestasis cirrhosis in the short term, which depends on liver transplantation. However, compared with adult
liver transplantation, children's liver transplantation has more postoperative complications and poor prognosis.
Therefore, it is of great significance if we can prevent this disease from maternal pregnancy and reduce its
incidence rate. Bile is synthesized and secreted in the liver, and then discharged into the gallbladder for
concentration and storage. It is periodically discharged into the intestine under the stimulation of food intake.
With the participation of intestinal flora, it regulates the metabolism and absorption of nutrients in the body.
Therefore, this paper discusses the treatment of cholestatic liver disease from the perspective of intestinal
microorganisms, and through the experimental simulation of rats, the results show that the structure of liver
lobules in the experimental intervention group is mostly destroyed or disappeared, and obvious hepatic fibrosis
appears, Fatty necrosis probiotics and ursodeoxycholic acid in 1 / 4-3 / 4 of liver tissue can reduce blood lipid
level, improve fatty liver, reduce liver inflammation and liver cell damage.