Application of Dermoscopy in the Early Diagnosis of Nail Moles and Subungual Malignant Melanoma

  • Lihua Liu
Keywords: Dermoscopy, Nail Moles, Subungual Malignant Melanoma, Early Diagnosis, Application Value

Abstract

To explore the application value of dermoscopy in the early diagnosis of nail moles and submalignant melanoma. 120 patients who were clinically diagnosed as or suspected to be nail moles and subungual malignant melanoma from May 2018 to May 2020 in the department were selected and divided into nail moles group (52 cases) and subungual malignant melanoma  group (68 cases). The patients were preliminarily diagnosed and re-diagnosed by clinical naked eye observation and dermoscopy, respectively. Finally, the gold standard method histopathology examination was used to confirm the diagnosis. The accuracy and sensitivity of two methods of clinical observation and dermoscopy were compared. In nail moles group, the accuracy rate of dermoscopy and macrography was (96.15%VS75.00%), sensitivity was (97.78%VS86.36%), specificity was (85.71%VS12.50%), misdiagnosis rate was (14.29%VS87.50%), missed diagnosis rate was (2.22%VS13.64%), the differences were statistically significant (P<0.05); Youden index was (0.835VS-0.011) and the acceptance score of dermoscopy and histopathology was [(92.35±4.89)VS (79.21±8.78) points], a nd the difference was statistically significant (P<0.05). In the subungual melanoma group, the accuracy rate of dermoscopy and macrography was (85.29%VS64.71%), sensitivity was (94.83%VS82.00%), specificity was (90.00%VS16.67%),  misdiagnosis rate was (10.00%VS83.33%), missed diagnosis rate was (5.17%VS18.00%). The differences were statistically significant (P<0.05); Youden index was (0.845VS-0.013) and the acceptance score of dermoscopy and histopathology was [(91.83±6.74) VS (75.68±10.32) points], and the difference was statistically significant (P<0.05). Dermoscopic examination has high sensitivity and specificity in the early diagnosis of nail moles and subungual malignant melanoma. The accuracy rate is much higher than that by macrography. At the same time, dermoscopy has the advantages of safety, non-invasiveness and easiness to operate and the patient acceptance is better.

Published
2020-05-01