Correlation between Quantitative Parameters of DCE-MRI and Differentiation Degree, Dukes Stage, Lymph Node Metastasis and Molecular Markers of Rectal Cancer

  • Chongquan Huang
Keywords: Quantitative Parameters of DCE-MRI, Differentiation Degree of Rectal Cancer, Dukes Stage, Lymph Node Metastasis, Molecular Markers, Correlation

Abstract

To analyze the correlation between quantitative parameters of DCE-MRI and differentiation degree, Dukes
stage, lymph node metastasis and molecular markers of rectal cancer. 92 cases were randomly selected from
rectal cancer patients admitted in our hospital from May 2017 to February 2019, and they were divided into poor
differentiation (12 cases), moderate differentiation (65 cases) and high differentiation (15 cases) according to the
differentiation degree, to compare the change of DCE-MRI quantitative parameters in patients with different
differentiation degrees. According to different stages of rectal cancer, they were divided into Dukes A stage (20
cases), Dukes B stage (44 cases), Dukes C stage (20 cases), dukes D stage (8 cases), to compare the change of
DCE-MRI quantitative parameters in patients with different stages; and according to the presence of absence of
lymph node metastasis, they were divided to 30 cases with lymph node metastasis and 62 cases without lymph
node metastasis, to compare their changes of DCE-MRI quantitative parameters; and according to the number of
Ki67 positive cells, they were divided into negative cases (4 cases), week positive cases (12 cases), positive
cases (25 cases) and strong positive cases (51 cases); according to the expression level of HER-2, they were
divided into low expression (60 cases) and high expression (32 cases), to compare the change of DCE-MRI
quantitative parameters under different expressions of Ki67 and HER-2. Pearson correlation test was used to
investigate the correlation between the quantitative parameters of DCE-MRI and the degree of rectal cancer
differentiation, Dukes stage, lymph node metastasis and molecular markers. The higher the differentiation
degree of rectal cancer, the higher the Ktrans and Ve (P< 0.05). With the increase of Dukes stage, Ktrans and Kep
increased gradually (P< 0.05). The levels of Ktrans and Ve in the group with lymph node metastasis were
significantly higher than those in the group without lymph node metastasis (P < 0.05). With the increase of
expression levels of Ki67 and HER-2, the levels of Ktrans and Kep increased gradually (P < 0.05). The Pearson's
correlation analysis showed that, Ktrans and Ve were positively correlated with the differentiation degree and
lymph node metastasis of rectal cancer, and Ktrans and Kep were positively correlated with Dukes stage and the
expression levels of Ki67 and HER-2 (P< 0.05). The quantitative parameters Ktrans, Ve, Kep of DCE-MRI are
correlated with the differentiation degree of rectal cancer, Dukes stage, lymph node metastasis and the
expression levels of molecular markers Ki67 and HER-2, which can indirectly reflect the biological behaviors of
rectal cancer tissues.

Published
2020-02-01