The Effect of Letrozole Combined with HCG on Reproductive Hormone and HGF Level in Infertile Patients with PCOS

  • Ping Yang
Keywords: Letrozole Study, Polycystic Ovary Syndrome, Infertility Study, Reproductive Endocrine Hormones

Abstract

Polycystic ovary syndrome (PCOS) is a common gynecologic endocrine in women of childbearing age,
metabolic disorders, according to the prevalence of polycystic ovary syndrome in women of childbearing age
about 7% - 18%, accounting for 20% of the patients with clinical endocrine disease of department of
gynaecology - 60%, pathophysiology and clinical manifestation, patients often show follicle selection obstacle,
follicle stagnation in the sinus follicle period, unable to form a dominant follicle, ovulation disorders, accounted
for 30% ~ 60% of patients with infertility. The purpose of this study was to investigate the efficacy of letrozole
combined with human chorionic gonadotropin in the treatment of patients with polycystic ovary syndrome (pcos)
and infertility, as well as the changes of reproductive endocrine hormones and HGF levels. In this paper, a
random number table was used to divide the patients into letrozole group, human chorionic gonadotropin group
and human chorionic gonadotropin group, with 50 cases in each group. The results showed that the ovulation
rates of letrozole group, human chorionic gonadotropin group and letrozole combined with human chorionic
gonadotropin group were 72.06%, 67.69% and 76.92%, respectively. The cycle pregnancy rate was 30%, 20%
and 40% respectively. After the injection of human chorionic gonadotropin, the VI and VFI levels of letrozole
combined with human chorionic gonadotropin group were significantly higher than those of letrozole group and
human chorionic gonadotropin group, the FI levels were significantly lower than those of letrozole group and
human chorionic gonadotropin group, and the ovarian volume was significantly smaller than that of letrozole
group and human chorionic gonadotropin group. It is concluded that letrozole combined with human chorionic
gonadotropin has an obvious therapeutic effect on patients with polycystic ovary syndrome and infertility, and
can effectively improve the clinical symptoms, signs and endocrine status of patients, and improve the
pregnancy rate of patients.

Published
2020-02-01